Admission

Biology Seminar: Minna Roh-Johnson, University of Utah

Friday, February 26, 2021 at 4:00 PMPacific Standard Time

Unconventional modes of intercellular communication can have large impacts in the context of homeostasis and disease. We have previously discovered that macrophages transfer cytoplasm to melanoma cells in vivo. Furthermore, 70% of melanoma cells that receive macrophage cytoplasm also disseminate from the primary transplantation site in vivo. These data suggest macrophages transfer a “package” of molecules that influence recipient cell behavior. However, central questions remain: 1) what is identity of the transferred molecules? and 2) how do these molecules influence cell behavior? We recently discovered that cell contact-dependent mitochondrial transfer occurs from macrophages to cancer cells. In contrast to previous held views on the mechanisms of mitochondrial transfer, our findings reveal that transferred mitochondria serve as a signaling source in the recipient cancer cell, rather than functioning as an energy-producing organelle. Our results suggest that macrophage mitochondrial transfer instruct cancer cells to become more robust and metastatic.

Please complete the form below to register for this session. You will receive a confirmation email after you submit your registration, which will include a link to the pertinent Zoom connection information. Please note that all times are listed in Pacific Time.

If you have any questions, please feel free to reach out to the Office of Admission at 503/777- 7511. We look forward to connecting with you!

Registration is no longer available because the registration deadline has passed.

back to top